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Oncolytics Biotech Inc. Message Board

  • carrivechio carrivechio Sep 9, 2013 1:32 PM Flag

    ONCY Positive News - Reovirus + carboplatin/paclitaxel combination = 32.7% ORR vs Phase III carbo/pac ORR = 25%

    ONCY's Phase II results in squamous cell lung cancer strongly appears to be demonstrating statistical significance with the introduction of reovirus compared to the historical carbo/paclitaxel standard.

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    • is the street story true? cant they sue him? the company would not lie???

    • In February 2013 ONCY reported a 33.7 % ORR which corresponds closely to today's announcement of 32.% ORR.

      02/08/2013 06:30:00

      Oncolytics Biotech® Inc. Announces Additional Positive REOLYSIN® Clinical Trial Data from Phase 2 Study in Squamous Cell Carcinoma of the Lung

      CALGARY, Feb. 8, 2013 /CNW/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX: ONC) (NASDAQ: ONCY) today announced results examining percent overall tumour shrinkage data from its U.S. Phase 2 clinical trial in patients with squamous cell carcinoma of the lung (SCCLC) using intravenous administration of REOLYSIN® in combination with carboplatin and paclitaxel (REO 021).

      The analysis examined percent best overall tumour changes between pre-treatment and up to six treatment cycles. Of 20 evaluable patients, 19 (95%) exhibited overall tumour shrinkage, (mean (20 patients): 33.7% shrinkage). A waterfall graph showing individual patient data will be available on the Company's website.

      "It's exciting to have 95% of patients in this study exhibit tumour shrinkage and these results further suggest that REOLYSIN may have potential use in neoadjuvant (pre-surgical) settings," said Dr. Brad Thompson , President and CEO of Oncolytics. "Based on these findings we intend to continue to look at REOLYSIN as a treatment for cancers of the lung and cancers that metastasize to the lung."

      The study enrolled patients with metastatic or recurrent squamous cell carcinoma of the lung. The primary endpoint of the study is objective tumour response rates, and the secondary objectives include progression free survival and overall survival. To date, the Company has observed nine partial responses (PR), nine stable disease (SD) and three progressive disease (PD) by RECIST criteria for a disease control rate (complete response (CR) + PR + SD)) of 86%. The study continues to enroll patients.

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