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Exelixis, Inc. Message Board

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  • califmale05 califmale05 Feb 24, 2012 10:43 AM Flag

    Dual Inhibition of MET and VEGF Signaling With Cabozantinib Blocks Tumor Invasiveness and Metastasis

    "To date, cabozantinib has shown activity in 12 of 13 tumor types studied, including particularly encouraging interim results in castration-resistant prostate, medullary thyroid, renal, liver, ovarian, non-small cell lung, and breast cancers, as well as melanoma. These results suggest that, in many types of tumors, cabozantinib may have a potentially differentiated activity profile as compared to compounds that inhibit only VEGF or MET."

    So many different permutations and combinations that only Big Pharma can truly afford to test and analyze!


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