This is the beginning. Now we shall see over the next while, just how big sales get, and what "Off Label" use happens. If I had METS, with nothing else available that does anything, I would be looking to my doctor and asking if I could use this drug. Why wouldn't you. Just give it a little time before the word spreads. Remember: fatal outcomes have a way of making people ask for something that appears to work. Think the informed are going to wait???