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Exelixis, Inc. Message Board

  • wilderguide wilderguide Jun 13, 2013 4:58 PM Flag

    Mass Gen hormone resistant mBC trial change

    Just wanted to point out an interesting protocol change that was posted with the 6/10/13 revision. I don't believe that combination treatment with fulvestrant was a part of the original trial design.

    "The single agent portion of this study is now closed to accrual. This research study is now examining the efficacy of cabozantinib in combination with fulvestrant for treatment of hormone-receptor-positive breast cancer that has spread to bone."


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    • Fwiw, this study (NCT01441947) was updated yesterday at clinicaltrialgov from 'recruiting' to 'ongoing, but not recruiting.'

      Sentiment: Strong Buy

    • $$$$
      There are a lot of publications that tend to explain the rationale for the combination of faslodex and cabo in mBC, but I couldn't find one more to the point than this study:

      "Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: implications for tumour-stroma interactions." PubMed 2006


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