Traditionally, there is a much larger pps increase after a positive Adcomm vote than there is for briefing doc release, regardless of the tone of the release. Examples are many, but recent ones include ARNA and VVUS, both of which had the Adcomm docs released in advance, but popped BIG on the positive vote. In both cases, the PPS after adcomm held, then increased more than 50% from there as the PDUFA date approached. In this case, the pps should get to over $22 by Wednesday, if the adcomm vote is positive. At $22, the market cap would still be a justifible, and arguably undervalued $680M. There is lots of upside to come!! It closed at $22 close to 18 months ago . . . it will definately break that high in the coming days!!