Population: 316,668,567 (USA July 2013 est.), 503,824,373 (EU July 2012 est.)
Per wiki, one in a million is born with HoFH
Income per Capita, $49,800 (USA 2012 est.), $34,500 (EU 2012 est.)
That means 317 potential patients in the USA and 504 potential patients from the EU, Total of 821.
Course it doesn’t take into account treatment alternatives, competition, or cost…
Per 2009 IRS Statistics the income cutoff for the top 1% of those who filed returns was $344K…1.4 million people in the USA earned more’n 344K in 2009, meaning roughly half of one percent (0.0044) of the population can afford the prescription out of pocket. Applying the income per capita ratio, it holds that 0.0031 of the euro population has enough to pay out of pocket…let’s just say 0.4 percent of population across the board as applied to USA and Euro persons could, if they wanted, afford the prescription out of pocket.
In the event insurance doesn’t cover 300K per annum prescription (with or without alternatives), the number of possible prescriptions drops to 3 or 4 (815 x 0.004) those who’re able to afford it out of pocket, whether or not they CHOOSE juxtapid is another story.