Rich Roberts discusses single-molecule sequencing technology with Biome reporter. part 2
What instigated you to write a commentary specifically on Pacific Biosciences’ SMRT sequencing technology?
There has been a misconception in the scientific research community that the method is very inaccurate. In fact it is the most highly accurate of all of the Next-Gen sequencing technologies available. This is because the errors, while high on a single read, are completely random and disappear statistically as more reads are made. A recent paper has shown that human polymorphisms can be found with greater accuracy using this technology.