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Vical Incorporated Message Board

  • ftwkram ftwkram Aug 15, 2012 11:59 AM Flag

    west nile

    getting a lot of press it is becoming a problem in TX..Does this co. have anything doing with west nile cause it sure seems like ti can use any help it can get

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    • Reasons why I like Vical's potential. you just never know which pipeline trial will benefit people in an unexpected way.

    • Yes, Vical had a NAIAD West Nile dna vaccine trial in 2005

      • 1 Reply to mesondk
      • West nile trial had positive results. Someone else posted this as well, but its worth repeating

        The West Nile virus DNA vaccine has been found to produce neutralizing antibodies in all fully-vaccinated volunteers during a phase I trial.

        Vical announced that in the clinical trial, a West Nile virus (WNV) vaccine candidate administered using Vical's proprietary DNA delivery technology was safe and well tolerated. It produced neutralizing antibody WNV-specific responses in all 11 healthy volunteers who returned for follow-up testing after completing the three-dose vaccination schedule. West Nile virus belongs to a group of disease-causing viruses known as flaviviruses that are usually spread by ticks or mosquitoes. WNV was first isolated in Uganda in 1937. It was found for the first time in 1999 in the New York City area and subsequently spread to other parts of the US, and by 2004 had been found in birds and mosquitoes in every state except Alaska and Hawaii. According to the US Centers for Disease Control and Prevention (CDC), WNV caused 2,949 cases of disease and 116 deaths in the US in 2005. "This vaccine was previously shown to be highly immunogenic in animal studies, and the high rate of seroconversion in humans, as measured in this study by neutralizing antibody titers, adds to the growing body of evidence demonstrating immunogenicity with DNA vaccines in humans as well," said Dr David Kaslow, Vical's chief scientific officer. "Furthermore, the data encourage investigation of vaccines against diseases caused by other flaviviruses such as yellow fever, Japanese encephalitis, and dengue, as well as other diseases for which antibody responses may be protective." The phase I, open-label clinical trial study was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and conducted at the NIH Clinical Center.

    • 16 deaths from West Nile in Texas. It's moving north. St. Louis had a few cases a year or so ago if I remember correctly. We have armadillos in Missouri now. Global Climate Change? I think so.

    • It's moving fast in New York according to the tv news today. Vijay said, when the government wants a West Nile vaccine we got one but you will have to support us.

      • 2 Replies to nycknowsbest
      • robertdurgin Aug 15, 2012 1:19 PM Flag

        I somewhat disagree with the statement, but understand why he said it. Vical claims to be a vaccine company but they do not have any vaccines lined up for the usual viral agents(not exotics by american standards) such as MMR, polio,Td URI virus's in P2 trial. Much of it has to do with the legal environment created around vaccines. I suspect they want a free ride and government backing for a West Nile virus. Even though West Nile is not deadly to most healthy folks it certainly is a miserable viral syndrome to work through and can resemble meningitis. I wish our government could get there arms around the medical liability industry because health care delivery would be considerably less costly and easy fixes such as vaccines could be instituted much more quickly. Attenuated viral vaccines should be a thing of the past or used as a secondary agent only. Besides trash and sewer management, vaccines are the number one reason for increased world life expectancies. It may require another true viral pandemic for society to realize this. Tired of rambling.

      • does this have serious legs folks?

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