Finn, Markovic, Joseph Therapies for Metastatic Melanoma, Past Present and Future
With approximately 13,000 annual deaths and a median overall survival (OS) of 8 to 18 months, metastatic melanoma is the most aggressive form of skin cancer . Until 2011, only two FDA therapies for metastatic melanoma were approved, dacarbazine and high dose interleukin 2 (HD IL-2), both of which do not increase median OS [2-4]. Dacarbazine is limited by a low response rate (10% to 15%) and an overall survival of eight months . HD IL-2 is limited by an even lower response rate (6% to 10%) and severe toxicity with only a minority of patients achieving a long-term, durable response [3,4].