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Vical Incorporated Message Board

  • bioprogene bioprogene Apr 3, 2013 8:56 PM Flag

    a7 mechanism and response rate

    One of the main characteristics of melanoma is its ability to escape immune detection through various mechanisms, such as the loss of expression of MHC 1. Therefore, the activation of immune system will have a profound effect on melanoma. Yervoy or anti-PD1, even overexpression of GM-CSF or IL-2 should work to certain extent, despite the fact that most cases are still beyond detection. A-7, on the other hand, puts a flag on the injected lesions, thus local response rate should be high. However, A-7 does not activate the global immune response (thus minimal side effect) and neither puts “flags” on the uninjected lesions. The global response should be minimal, in the low single digits. The combination of anti-PD1 with A7 might have an additive effect.
    Overall, the expectation is that the overall response rate should be between 6 and 11% with median survival extended by 2 months with a p value of 0.19 (not significant).

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