Do you have anything substantive to support this poor therapeutic index? The dosage is pretty high, 1-2 grams/day... Reported AE were mostly GI upset.
I would add another issue, i.e. unknown mode of action. If nobody knows why it works, then by extension they don't know what it does. Competing products are better understood, even though they are less mature.
If anybody has links to PK/tox studies, please share.