NEW YORK—Supplementing with nicotinamide riboside (NR), a novel form of vitamin B3, reduced metabolic and age-related disorders characterized by defective mitochondrial function in a recent study conducted by researchers at Weill Cornell Medical College and the Polytechnic School in Lausanne, Switzerland (Cell Metab. 2012 Jun 6;15(6):838-47).
Researchers showed high-dose NR supplementation prevented obesity in mice that were fed a fatty diet, and also increase muscle performance, improve energy expenditure and prevent diabetes development, all without side effects. The mice gained significantly less weight (60 percent) than mice fed the same diet without NR, even though the mice supplemented with NR ate the same amount of food. Many of the untreated mice on the high-fat diet developed diabetes. And when fed a normal diet, NR-treated mice had improved sensitivity to insulin. The NR treated mice also showed lower cholesterol levels.
The researchers also reported NR added to mammalian cells and mouse tissues increases nicotinamide adenine dinucleotide (NAD) levels, which activates sirtuin 1 and sirtuin 3 enzymes, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities. NAD allows sugars, fats and proteins to be converted into energy. Sirtuins are known to mimic a low-calorie diet and extend the lifespan of many organisms.
"This study is very important," said Anthony Sauve, Ph.D., associate professor of Pharmacology at Weill Cornell Medical College. "It shows that in animals, the use of NR offers the health benefits of a low-calorie diet and exercise — without doing either one."
He added, "The bottom line is that NR improves the function of mitochondria, the cell's energy factories. Mitochondrial decline is the hallmark of many diseases associated with aging, such as cancer and neurodegeneration, and NR supplementation boosts mitochondrial functioning."
The methodology the makes it possible to make NR commerci
The study, and the conclusion drawn by it are obviously flawed. Sorry Roxy. The amount of NR used is not disclosed. There is no comparison made with straight Niacin, which might have the same effect. And to state that "in animals" when you were using laboratory Mice, is a huge stretch. To extrapolate this to Humans, is unscientific at best, and misleading. There are so many substances that affect mitochondria, that you couldn't list them all. To flood a small animals system with any chemical, will obviously have many effects.
It would be nice to see a substance naturally found in milk, beer, and yeast products, act as a"super vitamin", but I have to say that amusing is the best adjective to describe these conclusions based on Science.
Mice are linked to humans through DNA in the evolutionary tree. It's not just coincidence why they use mice to test. Have some faith in science. Niacin comes with what they call a flush, so the comparison is inherently there, since NR has no side effects and Niacin does have a side effect. Why does the quanity of NR matter? Are you worried science can not produce enough for humans?
Would it be better if it was synthetic? Because how on earth could something natural be good for a human - those kind of natural things are only good for animals. I think I will wait for the pudding before accepting your proof. Imagine "the benifits of diet and exercise" without the dieting and exercise - now, who would need that? Remember this was discovered in the 60's and forgotten about until now. Do you really think Niacin would be around today if NR was out as it should have been in the 60's? Google, NAD this is real, it's all right there.