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  • dogdayevening dogdayevening Aug 12, 2005 3:07 PM Flag

    Depakote

    Anyone hear see the news out on the subject in fighting HIV?

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    • Yes, very interesting. Evidently some researchers have shown that Depakote actually destroys the HIV virus, and is being given some early kudos as a possible 'cure'.

      Amazingly, despite the TV news coverage, there's virtually nothing available on the Web that discusses the topic.

    • Researchers Work On Treating Dormant HIV

      POSTED: 1:15 pm CDT August 12, 2005

      LONDON -- A new treatment strategy has shown promise in helping to transform HIV into a curable infection.

      Preliminary research published this week in The Lancet medical journal outlines how scientists used an anti-convulsant drug to awaken dormant HIV hiding in the body, where it is temporarily invisible but still dangerous.

      HIV infection is incurable because current drugs only work when the virus is multiplying, which occurs only when it is in an active cell. However, HIV sometimes infects dormant cells, and when it does, it becomes dormant itself.

      While the virus poses no threat in its resting state, the sleeping cells sporadically wake up, reactivating the virus and causing it to multiply. Patients must continue to take medications for the rest of their lives so they can fight the virus when it comes out of the reawakened cells. Only if every last infected dormant cell is wiped out -- or the virus purged from these cells -- can patients stop taking medication and be virus-free, experts say.

      Figuring out how to clear this reservoir of latent infection, or whether that's even possible, is one of the hottest areas of AIDS research.

      Over the last few years, a handful of drugs have been shown to decrease the size of the dormant HIV pool, but they were subsequently abandoned because their effect was either too weak or the side effects too toxic.

      The latest drug, valproic acid, shows more promise, said Dr. Warner Greene, director of the Gladstone Institute for Virology and Immunology at the University of California, San Francisco.


      "The idea, if we could ever do it, is to purge every latently infected cell. Treat patients for probably two or three years, they'd be able to come off their antiretroviral therapy and they'd be virus-free," he said.

      The study, led by Dr. David Margolis at the University of North Carolina at Chapel Hill, tested the ability of valproic acid to reduce the number of infected dormant cells.

      Four patients on standard therapy were given the pills to take twice daily for three months. The size of this pool of infected dormant cells decreased by 75 percent in three out of the four patients, the study found.

      "This finding, though not definitive, suggests that new approaches will allow the cure of HIV in the future," Margolis said. "It's a significant conceptual move forward."



      Dr. Jean-Pierre Routy, a professor at McGill University in Montreal, Canada, who also studies the dormant HIV issue, said Margolis' results were an impressive first try.

      "It's enormous for just three months' treatment to have such an effect," he said, adding that the findings merit urgent further study. "I think it's very exciting news."

      However, other experts were less optimistic.

      "It's extremely unlikely that this approach would work," said Dr. Robert Siliciano, a professor of medicine at Johns Hopkins University who was one of the scientists who discovered the dormant infection problem in the mid-1990s. "It assumes something about the mechanism which we don't know is true. The mechanism may involve other issues that are not affected by this drug."

      "It didn't get all the cells. That's probably because it's not really targeting the right mechanism for latency," Siliciano said. "It's got to be a 99.9999 percent reduction to be useful. When you stop the drugs the virus explodes back so quickly, even if you had one latently infected cell left, in a matter of days you would be back to where you started from."

      Siliciano said he also doubts the valproic acid approach will solve the problem because it's likely HIV lies dormant in other types of cells that scientists have not discovered yet and tackling those reservoirs may require a completely different approach.

      "It's a little bit premature to be talking about a cure for HIV,"

    • The delivery mechanism (licking the frog's belly) just wasn't well received!!

    • >>You are so full of your crap that it becomes quite comical at this stage.<<

      Sadly, the only thing remotely comical here is contemplating the blustery, red-faced huffing and puffing you do as you pound the keyboard in your desparate attempts at face-saving.

      You've been exposed yet again as a pompous, foul-mouthed mountain of vanity who needs constant attention to feed your superiority complex driven self-image as an omniscient pedagogue.

      Remarkably pitiful....

    • Ponte, you pompous self-aggrandizing fraud:

      Here's the Lancet article summary. If you want to read the entire article, I'm afraid you'll need to be a subscriber as I am.

      I'm sure you'll have some final inane rejoinder -- as always, you'll be compelled to have the final word.
      ==========================================

      Summary
      Background
      Persistent infection in resting CD4+ T cells prevents eradication of HIV-1. Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains latency of integrated HIV, we tested the ability of the HDAC inhibitor valproic acid to deplete persistent, latent infection in resting CD4+ T cells.

      Procedures
      We did a proof-of-concept study in four volunteers infected with HIV and on highly-active antiretroviral therapy (HAART). After intensifying the effect of HAART with subcutaneous enfuvirtide 90 �g twice daily for 4�6 weeks to prevent the spread of HIV, we added oral valproic acid 500�750 mg twice daily to their treatment regimen for 3 months. We quantified latent infection of resting CD4+ T cells before and after augmented treatment by limiting-dilution culture of resting CD4+ T cells after ex-vivo activation.

      Findings
      The frequency of resting cell infection was stable before addition of enfuvirtide and valproic acid, but declined thereafter. This decline was significant in three of four patients (mean reduction 75%, range 68% to >84%). Patients had slight reactions to enfuvirtide at the injection site, but otherwise tolerated treatment well.

      Interpretation
      Combination therapy with an HDAC inhibitor and intensified HAART safely accelerates clearance of HIV from resting CD4+ T cells in vivo, suggesting a new and practical approach to eliminate HIV infection in this persistent reservoir. This finding, though not definitive, suggests that new approaches will allow the cure of HIV in the future.

    • What an absolute piece of work you are!!!

      The article is BRAND NEW, from the August 13th, 2005 issue (Vol 366, pp 539 et al). The work JUST NOW BEING REPORTED is unique.

      Once again, you have been shown to be the arrogant, pompous, self-important jackass that you so consistently demonstrate ad nauseum to this board.

      Your only response is to attempt to impugn the integrity of the ones who expose you for the fraud you are.

      You recommended Depakote for me. Psychologists recognize this as TRANSFERENCE - the need for disturbed persons to ascribe to their acquaintences the symptoms and treatments for their own diseases. Your bi-polarity is quite evident.

    • Lad

      Your pushing the right buttons fer sherr. I had never heard of transference, are you an acquaintence (spelling) of supernal Ponty?

      Captious statement! Kiki

    • Kiki:

      Sadly, all of us here are are forced acquaintances (thx for spelling note) of the insufferable pompous one.

      Captious statements, perhaps, but laser-precision accurate nonetheless.

    • Kid:

      Very nicely stated, I couldn't agree more.

      Lad

    • ....by the way, I'm sure you know one of my alter-ego IDs is carrion_kid. You'll find my posts often on the HSP board.

      But, as you have mis-spelled 'carrion' in your particular persona, presumably to mimic me, it's ironic that you also chose to correct the spelling of 'acquaintance'.

      As the song Itchycoo Park says, "..it's all too beautiful.."

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