I am riding the fence on this one. I neither subscribe to " RS is imminent" nor do I believe you have provided any evidence that success is imminent...I don't care how long you have "been around". Look at your own statements..."IF Z160 and then Z944 succeed"..."WHAT MAKES YOU THINK that a 2x can't happen"..." it's not only probable but ALMOST SURE" ..."Zalicus’ Z160 ...is selected as a Top 10 Project TO WATCH." Tell me, where in all that conjecture is any modicum of fact to base your pseudoguarantee of success other than " you have been around"? I have " been around" as well; certainly long enough to know that no drug is a guarantee until it is stamped "approved" by the FDA. If you have been around as long as you claim, you would know all this and provide something other than conjecture to support your contention of "almost sure." These like all drugs are a risk...plain and simple. There is no getting around that. When it comes to Pharma..it is legalized gambling, so invest what you can afford to loose and hope for the best when you pull the lever, roll the dice or spin the wheel.