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Synergy Pharmaceuticals, Inc. Message Board

  • herkyhawk00 herkyhawk00 Mar 11, 2014 10:47 AM Flag

    Why is SP-333 being used for OIC & not Plecanatide?

    Was hoping I could get some feedback with this. With the great results from plecanatide in a large phase II in patients with CIC, why not use Plecanatide also for OIC? Seems that with both Linzness and Amitiza being used for OIC, I am confused why Plecanatide isn't and SP-333 is?

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    • How does SP-333 differ from Plecanatide?
      SP-333 is similar to Synergy’s first GC-C agonist peptide, plecanatide, except that the N- and C-terminal amino acids have been altered to reduce the potential for proteolytic degradation in the gut.

      In English
      SP-333 is a modified version of Plecanatide. SP-333 will probably show results with even less diarrhea than Plecanatide. Why did Pfizer promote Celebrex and Bextra? This move will allow SGYP's GC-C drugs to gain more marketshare and make more $$. If SP-333 has less diarrhea due to it's modified structure, doesn't matter what the indications are, physicians will use it. Some of this I am speculating on, however, SP-333 is a modified Plecanatide and you can speculate the reasons behind it too.

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