darkouttonight by darkouttonight. 0 seconds ago .Permalink
Isis 2.5 still does not have precise specificity and on a bad day will bind to a mouses testicles. Antisense is good for targeting as I have always stated. The nice part of antisense is that it can be designed to treat a wide range of diseases. Yup, Isis can come out with a new drug every week. ( This looks great to a newbie analyst) The bad part is that they don't work well enough to successfully pass a large scale phase 3 clinical trial other wise the stock price would be $500 a share. THEN, there is the dark nuclease digestion problem. NOW, how did I know five years ago that MIPO would fail... it's called common sense. Oh, BTW, do you remember when I warned you all with regard to the Kidney, Liver and bone marrow TOXIX attacts ? A few times I slipped in the Cancer warning too. Wow, how you poor people screamed at me. Do you really want me to go on? Bottom line, antisense has a great story for insiders to rake in the dough for decades and they have created great wealth for themselves etc. Nope not you... sorry. : ( I wish you all good health ! : )
You left out that is will likely cause chronic systemic inflammation which would be expected to increase risk for someone with an already astronomical risk of heart attack. I give this 5 years max before its pulled from the market.
2nd generation antisense does have some toxic problems but they have their place.Now 3rd generation antisense such as Sarepta's ''srpt'' does not have toxic effects of any known..i see them as the number one leader in the future.