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Isis Pharmaceuticals, Inc. Message Board

  • dinepat203 dinepat203 Jan 17, 2013 9:15 AM Flag

    CRL for Kynamro is Risk to entire ISIS pipeline as all depends on ‘antisense oligonucleotide’

    The active substance in Kynamro, mipomersen, is an ‘antisense oligonucleotide’, a very short fragment of DNA designed to block the production of a protein called apolipoprotein B, by attaching to the genetic material of cells responsible for producing it. Apolipoprotein B is the main component

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