I forgot to mention in my previous post: I'm not sure why they are using antisense to lower CRP levels. When they were studying heart disease, they just used N- acetyl- cysteine, an orally administered modified amino acid found in many supplements, to lower the CRP. Maybe they think you have to stop the body from even producing CRP.
It could be a blockbuster, but it is a real longshot. Years ago,
when it was found that patients with elevated CRP, which is a marker for inflammation, had high risk of heart disease, there was excitement, but they found that lowering the CRP did not improve their prognoses. The experts decided that CRP was just a non-causative marker for heart disease. That is why most drug companies dropped research on CRP. Isis may be on to something, but they are just about alone in their opinion on this. I think that's why they keep trying to justify their efforts. I hope they are right, for more than just financial reasons.
I don't think it's such a longshot, the evidence has mounted that higher crp levels are directly linked to mortality and morbidity in a multitude of ailments.The evidence appears to link crp to having a cause and effect relationship. It was probably too late for those patients for that indication.