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Isis Pharmaceuticals, Inc. Message Board

  • darkouttonight darkouttonight Aug 10, 2013 8:39 PM Flag

    Look folks even my friend BatWing knows the serious flaws of antisense drugs & he doesn't study same !

    In 2008 I put a Strong sell on Isis at $23 & for you to buy Vical under $1.80. Then in March 2012 I put a strong buy on Isis at $7.16 due to the fact biotech stocks were starting to rip up-side. I still knew that antisense could only silence approx. 80% of the disease protein being produced... this means 20% of the disease was free to roam the body not to mention the terrible side-effects. After all of this time the pharmacokinetic (lack of stability in the body) the clearance, site specific delivery and plasma half-life, blood clotting time, complement activation & liver effects, thrombocytopenia.......... Wait a minute I could go on & on but I'm tired of attempting to educate clueless funds that manage and control Billions of their clients money. As I've stated since 2000, " antisense is good for targeting and that's where it ends!" Why else would the CEO farm out all every early clinical trial rather than save it for Isis ? He stated years ago that he would not farm this revolutionary platform to big pharma. ( I have his statement in print so let's stop the hype.) You don't really want me to explain why enzymes and other cellular, and cellular pharmacokinetic factor into the serious problems of antisense drugs. Forget the Barrons article as they were very kind to Isis, actually, Ableson (sp) has a 99% more to learn with regard to antisense!

    I could go on & on but I'm more interested in Vical's technologies, at least it's safe ! Good luck folks, I remain darkouttonight. : )

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