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ONYX Pharmaceuticals, Inc. Message Board

  • bishoppetersenbuilders bishoppetersenbuilders Dec 9, 2006 11:15 AM Flag

    Melanoma

    I was not surprised by results in melanoma...What is going to be effective against metastic melanoma? I was shocked at the dip in price...having bought in around...21 this was painful. I still think nexavar gets approval for liver and possibly lung. I think off label use is expanding in liver and next revenue report should put us back to where we started.

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    • I agree.

    • Do you know if Bayer's expectation of 1 bil sale includes melanoma or not? I would say they expect 1 bil without melanoma.

    • >>What is going to be effective against metastic melanoma? I was shocked at the dip in price...having bought in around...21 this was painful. I still think nexavar gets approval for liver and possibly lung.<<


      You think metastatic liver and metastatic lung cancer are easier than metastatic melanoma!??? Do you think the P1/2 evidence is any stronger in liver and lung than it was in melanoma???

      It is all single arm stuff they are going by. Not much better than reading tea leaves. The company all but admitted on the last cc that picking pivotal trials on the basis of single arm hints was a mistake. Now they will go after any big $$ cancer where anti-angiogenesis seems to have a chance, combining with other drugs which have shown efficacy in those cancers.

      Big expensive crap shoots from here, the way I see it.

      Still, the drug works in RCC, so it might work in something else. Spend enough money and you might get lucky. But their strategy was a mistake. They could have carried out a dozen ~100 patient two-armed studies by now and have a couple clear signals for P3 beyond RCC.

      micro

    • I agree. Do you know when next earnings come out? I looked at Yahoo Company Events and didn't see it. I just bought some at the close Friday. I too thought the drop was over done. I also read a Jim Jubiak article on it. Stating the same thing, and adding it to his picks.
      I think once everything is settled and people realize that this big drop was in part because of Pfizer's failure, it will come back strong. If not, I hope Bayer buys us out.

 
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