treatment. ran across an article (summary
follows) in september 10 issue of science. instead of
trying to express the p53 gene, these people are
inhibiting p53 production to eliminate side effects of
chemotherapy and allow larger dosage to destroy cancer. any
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A Chemical Inhibitor of p53 That
Protects Mice from the Side Effects of
Pavel G. Komarov, 12* Elena A. Komarova, 1* Roman V.
Konstantin Christov-Tselkov, 3 John S.
Coon, 2 Mikhail V. Chernov, 4
Andrei V. Gudkov 1
Chemotherapy and radiation therapy for cancer often have
effects that limit their efficacy.
Because these effects are in part
p53-mediated apoptosis, temporary suppression of p53 has
been suggested as a therapeutic strategy to prevent
damage of normal
tissues during treatment of
p53-deficient tumors. To test this
possibility, a small
molecule was isolated for its ability to reversibly
block p53-dependent transcriptional activation and
compound, pifithrin-, protected mice
from the lethal genotoxic stress
anticancer treatment without promoting the formation of
tumors. Thus, inhibitors of p53 may be useful drugs for
side effects of cancer therapy and other
types of stress associated with
1 Department of Molecular Genetics, University of
Illinois at Chicago,
Chicago, IL 60607,�USA.
Department of Pathology, Rush Presbyterian St. Luke's
Chicago, IL 60612,�USA.
Department of Surgical Oncology, University of Illinois at
Chicago, IL 60612,�USA.
Institute, Cleveland Clinic Foundation, Cleveland, OH
5 Quark Biotech, Pleasanton, CA 94566,�USA.
*�� These authors contributed equally to this work.
�� To whom correspondence should be addressed.
Sadly, ONXX has become a day trader target, it is small enough that with a concerted effort, they can drive the price up or down enough for them to make a profit, problem is, it turns off investors.
And actually, following the Beta through Level 2
on a stochaistics surge, where the Mac D makes ya
jump, jump, I can safely conclude you're a total
As far as CHIR, hmm, maybe they have more shares
than I thought. Been in this thing for going on 18
months now, they were always selling, thought they were
done. I'd trust your info more than my intuition (by a
But don't sweat the share price.
It'll go up fast as soon as the Phase III is
(Maybe you really can jump in and out of stocks, this
one is staying low enough, but I wouldn't recommend
it: odds are good you'll get burned sooner or later,
plus it's 50-50 whether they'll change the laws enough
so that investing in a capital-intense small cap
firm (like a biotech), will be cap gains tax free if
you hold on for three years -- like it already is for
Don't expect anything quick,
if you heard Hollings on that interview, he really
didn't wow anybody, so the hype factor for this stock is
a small one. Hardman's clearly a genius, but it
remains to be seen how he'll do in crowds and on the road
show. (But the deal itself is so huge. And if anything
should happen in IMCL's testing or patents, dat's when
you expect ONXX to explode.)
Bad PR factored
in and assuming IMCL hits, it's 20-30 when Onyx
announces, 40-50 if they get fast track, 100++ when
approved, and then we talk revenues and pricing. Put this
one away and go to sleep, they'll not be impacted by
I freed up a large block of 80
You might have seen my trade drop the price a
I am watching eagerly for new
Should be interesting to see what happens with the
negative beta that Onyx enjoys when the Feds announce the
coming interest rate hike.
Should boost the
Good Luck to all.
you said,"CHIR has been
selling their stake in ONXX for over a year now, believe
that 50,000 was the last of their shares."
is your source for this information? can you be more
specific? how much has Chiron sold this year?
have been blaming the lack of ONXX price increase on
Chiron stock dumping for several years - and at one time
is was probably true to some extent. Chiron reduced
its stake in Onyx from 1.4million shares to about
884K (sold 500K shares)from 1997 to 1998, but only
sold about 134K shares from the april '98 DEF 14A to
the april '99 DEF 14A! Furthermore, so far this year
I can only find the sale of 50K shares from April
99 to now - not exactly share dumping.
have more accurate info about Chiron share dumping,
please share it.
Daytraders having their fun, MMs forcing the
price between 8 15/16ths and 9 1/16ths. Period. That's
the range (I had a limit order this morning for 8
3/4ths, never got filled. Moved up to
CHIR has been selling their stake in ONXX for over a
year now, believe that 50,000 was the last of their
Wait for the Phase III announcement. And for anyone
who thinks this is "dead money" until
Yeah jackass. Go buy MO.
Hold it and don't
counting the 180K shares that changed hands today
(including some quite large blocks) 1.5 million share have
traded since last monday's announcement. The float is 10
million = so 15%. This kind of volume hasn't been seen
for awhile by onyx and let's hope it is a signal of
significant "retrenchment" at this price. That is a lot of
new owners that will hopefully hold for awhile and
provide a a solid base for a move upwards. Also, let's
hope some of those large blocks that moved today were
big boys (and girls) taking notice.
thoughts on the volume?
I don't understand.
Who is Chiron?
would this cause such a downward trend on the stock
price. I saw that deal go through.
I still don't
understand why ONXX, which has now enough media coverage and
suggested market confidence continues to do
This is a stock which I just do not
I tend to agree with the previous poster who
suggested that there are a lot of long term holders who
just could not cope with the fact that the price
peaked a bit when the WLA news hit.
buying, followed by long-termer sell-off and profit
taking. Only explanation.
Thanks for followup.
Any other "tips" would be greatly
Should I sell my huge block and get out now? I would
prefer to free up some money and mobilize it on
something that moves a bit more predictably.