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công ty Qiagen NV Message Board

  • donjsallin donjsallin Jan 23, 2008 12:07 PM Flag

    CytoCore message board

    is finally available on Yahoo for those interested.

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    • These �conflicting observations� support our hypothesis that mammary epithelial cells that partly lose control in proliferation are more susceptible to persistent HPV infections. It has been suggesting that partly lost control in cell proliferation is one of the earliest carcinogenic steps towards breast cancer [23]. High proliferation of the infected host cell has been considered to be crucial for the persistence of HPV infections. When HPV infects a basal layer cell of the cervical stratified squamous epithelium, the HPV DNA only replicated during cell divisions of the hosts before the differentiation of the infected cells. This allow the copies of virus DNA preserves in a large of number of premature cells [24]. In a similarly way, after infected a mammary epithelial cell that partly loses control in proliferation the HPV DNA copies may preserve in nearly every clone of its first host. The preserved HPV DNA may further interact with other carcinogenic factors, and involve in the later carcinogenic steps of breast caner. Nevertheless, a normal premature mammary epithelial cell is expected to have a much lower rate in proliferation than a basal cell of the stratified squamous epithelium from the cervix or the skin. This could also explain why HPV infection in normal breast gland tissues is extremely rare if there is any.

      from pubmed #17656036

    • I sent some somments to the Editor at Forbes (complaining of their use of the word "new" for the HPV test, etc) and just got a reply that the letter is "being considered for publication" ...hold your breath

 
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