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Ligand Pharmaceuticals Incorporated Message Board

  • long_vrts2 long_vrts2 Jan 22, 2013 3:18 PM Flag

    Case report: Promacta + romiplostin effective in severe thrombocytopenia

    Hematology. 2013 Jan 8. [Epub ahead of print]

    Simultaneous romiplostin, eltrombopag, and prednisone were successful in severe thrombocytopenia of Evans syndrome refractory to hydrocortisone, splenectomy, intravenous IgG, and rituximab.
    Ruiz-Arguelles GJ, Ruiz-Delgado GJ, Velázquez-Sánchez-de-Cima S, Zamora-Ortiz G.
    Abstract

    A 58-year-old woman presented with rheumatoid arthritis-associated Evans syndrome (simultaneous autoimmune hemolytic anemia and autoimmune thrombocytopenic purpura); she was treated unsuccesfully with steroids, romiplostin, rituximab, immunoglobulin G, and splenectomy. The platelet count responded to the combined use of prednisone, eltrombopag, and romiplostin. It may be more reasonable to use combined treatments than sequential monotherapies.

    PMID:
    23321502
    [PubMed - as supplied by publisher]

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