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  • advisor321 advisor321 May 20, 2010 3:13 PM Flag

    Crippled US soldiers DENIED TYSABRI but OK for Lawyer?

    Methylprednisolone has been shown to minimally help some rats with spinal injury.
    Methylprednisolone is not Tysabri.
    Natalizumab is Tysabri.

    Tysabri would absolutely have no effect on spinal injuries.

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    • <Tysabri would absolutely have no effect on spinal injuries. >

      Sounds like you'd be one of those supporting the German hospitals caring for our crippled heroes, instead of giving them

      ONE INFUSION of TYSABRI shortly (within 2 hours) after they're hurt....

      But I'm going to give you the benefit of the doubt & trust you to read the link I'm providing below, along with the publication, title, & authors. After you read it, please comment on your above comment.

      http://www.ncbi.nlm.nih.gov/pubmed/19929361
      J Neurosurg Spine. 2009 Nov;11(5):575-87.

      Timing and duration of anti-alpha4beta1 integrin treatment after spinal cord injury: effect on therapeutic efficacy.
      Fleming JC, Bao F, Chen Y, Hamilton EF, Gonzalez-Lara LE, Foster PJ, Weaver LC.

      Spinal Cord Injury Laboratory, The University of Western Ontario, London, Ontario, Canada.

      just to be helpful, I'll point out a couple of phrases from the abstracts

      "After spinal cord injury (SCI) leukocytes infiltrate the injured cord, causing significant damage and further impairment of functional recovery. The leukocyte integrin alpha4beta1 is crucial for their entry. The authors previously demonstrated that an anti-alpha4 monoclonal antibody (mAb) treatment attenuates leukocyte infiltration, improves motor and autonomic function, and reduces neuropathic pain when administered at 2 hours and 24 hours after SCI. "

      The ONLY anti-alpha4 monoclonal antibody that is both FDA & EMEA approved is TYSABRI.

      Here is a Canadian drug bank link to Tysabri (aka natalizumab aka anti-alpha3 integrin monoclonal antibody aka an alpha4beta1 mAb aka a very late antigen4 (VLA-4) mAb or an anti-CD49d mAb) :
      http://www.drugbank.ca/drugs/DB00108

      Methylprednisolone which is a steroid is considered the standard of care for spinal cord injury SPI simlar link here:
      http://www.drugbank.ca/drugs/DB00959

      Why don't your want our CRIPPLED HEROES fighting against terrorism and for our freedoms here in the USA to walk?

      Why is it ok for former US President Bill Clinton, Secretary of State Hillary Clinton, Senator John Kerry, & others to FIGHT for California lawyer Baron Budd to get TYSABRI, but they're completely SILENT on whether our CRIPPLED SOLDIERS can't get this drug to help them walk?

      Will you tell Vern Beachy & others posting on youtube.com to be SILENT about how this WONDER DRUG called TYSABRI helped him & others get out of their wheelchair?

      Are you a human being in the USA who cares about our CRIPPLED HEROES?

      Or is something else more important to you?

    • Minimal help as methylprednisolone diminishes inflammation & thus pain, but has no effect on getting the crippled to walk.

      Methylprednisolone is certainly not TYSABRI (aka natalizumab aka alpha4beta1 integrin blocker aka anti-alpha4beta1 monoclonal antibody).

      Methylprednisolone is a steroid. Here is a link to it-
      http://www.drugbank.ca/drugs/DB00959

      Tysabri is a selective adhesion modifier that helps release stem cells from the bone marrow. Here's a link from Canada to it-
      http://www.drugbank.ca/drugs/DB00108

      While methylprednisolone helps reduce inflammation & pain, it doesn't help our crippled heroes walk. But TYSABRI would...if the captured media or true American patriots would write their Congress...

      http://www.ncbi.nlm.nih.gov/pubmed/19038604
      Exp Neurol. 2008 Dec;214(2):147-59. Epub 2008 May 1.

      Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves neurological function.
      Fleming JC, Bao F, Chen Y, Hamilton EF, Relton JK, Weaver LC.

      Spinal Cord Injury Laboratory, BioTherapeutics Research Group, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5K8.

      ****
      The authors state that "motor function improved by up to 2 points on an open-field locomotor scale. Treated rats supported weight with their hind paws instead of sweeping."

      What this would mean to a human is that instead of dragging along your limp legs, they would actually SUPPORT YOUR WEIGHT while STANDING ON YOUR LEGS.

      Why won't you SUPPORT MY EFFORTS to bring this SIMPLE TRUTH to the public's attention?

      Bill & Melinda Gates aren't. Neither is Warren Buffet.
      They obviously are too busy making MONEY for themselves or are too busy with their PET PROJECTS of saving lives by making vaccines for the UNDERPRIVILEGED to care about our

      ....CRIPPLED HEROES that FIGHT AGAINST TERRORISM in IRAQ & AFGHANISTAN...

      So what's your excuse?

 
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