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Biogen Idec Inc. Message Board

  • oexwiz oexwiz May 11, 1998 12:07 PM Flag

    Bexxar vs. IDEC-Y2B8: Iodine-131 vs. Ytt

    In a recent press release from IMMU, another
    biotech involved with monoclonal antibodies, they state
    they are going to try Yttrium-90 instead of
    Iodine-131. They hope to achieve better response rates and
    say:

    "Until now, Immunomedics has used antibodies labeled
    with radioactive iodine (I-131). Its latest trials
    will attempt to improve response by substituting
    Yttrium-90 for I-131. This will also allow the patients to
    be treated on an outpatient basis and to return home
    after receiving the therapy."

    Bexxar uses
    Iodine-131 (requires isolation/shielding) and is one reason
    I like IDEC (IDEC-Y2B8) and IMMU (LymphoCide)
    better for "hot" antibodies. The biggest downside to
    Yttrium is that it acts much like calcium and has an
    affinity for bone.

    SortNewest  |  Oldest  |  Most Replied Expand all replies
    • Just re-read your post and see that you said "(yttrium) acts like calcium and has an affinity for bone."

      Maybe I misunderstand what that means. What does it mean?

      • 1 Reply to berblady
      • As i understand it, bones will uptake
        yttrium(-90) just like calcium and may cause longer term bone
        marrow damage beyond what other "hot" anti-CD20
        antibodies do in the normal process of attaching to CD20+
        lymphocytes. (There are some approaches to minimizing this.)
        On the other hand, less yttrium-90 tagged antibody
        is needed to be effective (supposedly).

        It
        appears that the risk/reward is worth it since now at
        least two companies, IDEC and IMMU are using it.

 
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