here is my patient handout for belviq...part one.... steven vig md
BELVIQ IS A PILL TO HELP YOU LOSE WEIGHT (patient information)
BELVIQ (lorcaserin) is a 5HT2C serotonin receptor agonist that works in the hypothalamus area in the brain to decrease appetite and help you lose weight. Belviq does not raise your blood pressure or your heart rate. Belviq was approved by the FDA in 2012 and will be available in pharmacies in the United States in March, 2013. Belviq is a prescription medicine from Arena Pharmaceuticals and Eisai. Belviq is given as one 10mg pill twice a day, with or without food. Along with diet and exercise, Belviq is indicated for weight loss in obese patients (Body Mass Index of 30 or higher). Belviq is also indicated for weight loss in overweight patients (Body Mass Index of 27 to 30) who have weight related conditions like diabetes, high blood pressure, or high cholesterol. The most common clinical side effect was headache, which was seen in 16.8% of patients compared to 10.1 % of patients on placebo. The headache was mild and tended to go away in a few days, even when Belviq was continued. Belviq will be a schedule IV drug, which would be the same as the sleeping pill temazepam. Your doctor may need to obtain prior authorization from your medical insurance to get approval for you to use Belviq. You should see your doctor 12 weeks after starting Belviq to be sure that the drug is working for you, and that you have lost at least 5% of your body weight in the first 12 weeks on Belviq. For example, a 200 pound person should lose at least 10 pounds in 12 weeks, and a 260 pound person should lose at least 13 pounds in 12 weeks.
end of part one
Sentiment: Strong Buy
You really are a nut case. You tell your patients the name of the company that sells the drug you are promoting??? "the hypothalamus area in your brain" what are you, a physician who caters exclusively to neuroscientists? ...and by the way tramadol - not an antidepressant and probably your highest risk med for serotonin syndrome. And if by any very remote chance you really are a doc, you should tell your patients the symptoms of serotonin syndrome, not that it can "excessively raise serotonin levels" what a joker you are!!! Safe to say you didn't go to any of the medical schools that I have been affiliated with. I make fun of the losers on the VVUS board, but really you are doing nothing positive for my investment.
Sentiment: Strong Buy
Cheers, DrVig.... This reads very factual and well-balanced. I also saw you had a comment in on the DEA docket.... also from the Obesity Action Coalition and the Obesity Society. Thanks to you all for submitting real fact based comments to counter some if the misinformation or outright lies by others.
patient handout for belviq...part two.... steven vig md
Serotonin Syndrome is an uncommon complication which can occur if two or more medications are given at the same time that can excessively raise serotonin levels in the brain. Extreme caution should be used if Belviq is given along with SSRI antidepressants ( like fluoxetine, paroxetine, sertraline, citalopram, and escitalopram), SNRI antidepressants (like venlafaxine, Pristiq, and Cymbalta), tricyclic antidepressants ( like amitriptyline or nortriptyline), bupropion, trazodone, tryptan migraine medications (like Imtrex/sumatriptan), MAOI antidepressants, lithium, tramadol, or over the counter supplements like St. John’s Wort, tryptophan, or dextromethorphan (Robitussin DM). There is another rare complication called Neuroleptic Malignant Syndrome, associated with excessively lowering dopamine levels in the brain. Extreme caution should be used if Belviq is given along with medicines that lower dopamine, like antipsychotic medications for schizophrenia (Zyprexa would be an example of an antipsychotic).
Belviq should not be used in pregnant or breastfeeding women. Belviq should not be used in patients with severe kidney disease (creatinine clearance under 30) or in patients with severe liver disease. Belviq is a mild to moderate inhibitor of cytochrome P450 2D6 and can raise the levels of substrates that are metabolized by this enzyme Belviq might lower the effectiveness of tamoxifen. Belviq is not likely to have a strong interaction with warfarin.
Be sure to diet and exercise along with your Belviq. Good luck with your efforts to lose weight !!!
Steven Vig, MD Internal Medicine Tucson, Arizona March 2013
Sentiment: Strong Buy