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SIGA Technologies, Inc. Message Board

  • mocastinstone mocastinstone Dec 8, 2009 7:30 AM Flag

    Can SIGA Modify ST-246, 699,other

    and develop an anthrax vaccine or cure?

    Has SIGA worked on anthrax?

    Does BARDA know something we don't about SIGA's capabilities or potential capabilities?

    Hmmm,NWGUV?

    IMO


    My PIP hedge went bye-bye with that cancellation BUT perhaps SIGA's
    appreciation will trump the PIP loss?

    SortNewest  |  Oldest  |  Most Replied Expand all replies
    • You been drinking the Kool-aid too?

    • ...let's not to get too far ahead of ourselves...Siga's current pipeline hopefuls have been targeting mainly viruses with brief mention on some anti-sortase drugs targeting bacterias advancing to the preclinical stages. Although there was some talk about this noval application of these drugs, it still has a long way yet on the antibacterial front development.
      SORTASE:
      SIGA has identified the critical role of sortase, an enzyme that is part of the pathogenesis of Gram-positive bacteria. In developing an agent to inhibit sortase, SIGA has discovered a way to prevent such bacteria from colonizing and causing disease.
      SIGA’s sortase anti-bacterial is intended to be effective against Gram-positive bacterial pathogens, including Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis, Streptococcus pneumoniae, and resistant derivatives. A sortase anti-bacterial could also be administered against biodefense targets such as Bacillus anthracis, Clostridium botulinum, and Listeria monocytogenes.
      SIGA has identified several series of compounds that have shown potent in vitro activity against sortase. SIGA is now in the process of advancing them to the preclinical stage

      • 2 Replies to serendipme
      • BUMP.

        Thanks for the great response.

        Do you think SIGA could meet the BARDA 8 year challenge/rqmt for approval?

        I was amazed at the
        haircut EBS & PIP got in premarket & no acty on their MB.

        I was also dismayed that in pre-market
        SIGA was flat when it should have been
        moving up with the PIP/EBS cancellations!

        SIGA should really be benefitting from the EBS/PIP cancellations,esp with an anthrax potential.

        SIGA PPS & interest should be up & really take off with positive news imo.

        And then there is the no float as the MM's are discovering?

        Any papers on the SIGA anthrax possibilities?

        EBS & PIP are opportunities for risky bets. EBS because of its products and PIP for their "connections",NWGUV?

        IMO

        Hold with your & your neighbors' fists!

    • I believe SIGA does have an anthrax drug that could be a potential candidate. It was put on the back burner with small pox ST-246 the primary focus. Perhaps we have another potential revenue stream in the future.

    • Change "699" to "669".

 
SIGA
1.38-0.04(-2.82%)Dec 18 3:59 PMEST

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