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  • sigakingone sigakingone Nov 18, 2013 5:03 PM Flag

    Development and Characterization of an Intranasal Mousepox Model

     

    Development and Characterization of an Intranasal Mousepox Model
    Southern Research Institute has been awarded a task order from the U.S. Department of Health and Human Services, Biomedical Advanced Research and Development Authority (BARDA), to complete development and characterization of an intranasal mousepox model.

    Mousepox (which is caused by the Ectromelia virus) is one of three animal models useful for development of medical countermeasures for smallpox. Southern Research Institute has already validated the non-human primate and the rabbit models for human smallpox for compliance with the FDA Animal Rule. Addition of the murine ectromelia virus model completes Southern Research’s portfolio of animal models used to develop medical countermeasures for smallpox, to study basic questions in disease pathogenesis and to develop countermeasures to orthopoxviruses engineered for enhanced virulence, transmissibility, or the ability to break through vaccine immunity.

    Briefly the scope of work for this contract is as follows:

    Generate virus stocks - master and working seed banks following a qualified quality control plan
    Determine LD50
    Determine the natural history of the disease to define onset and progression following infection
    Characterize the model for use in assessing anti-viral therapeutics designed to identify treatment triggers
    Create a Technology Transfer Package such that BARDA may use the model in many laboratories to support its Medical Countermeasures (MCM) program
    Model development work has already started and is expected to be completed in 2014.

    Zip4pip
    long and Strong

    Sentiment: Strong Buy

    This topic is deleted.
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