The January 12 issue of Forbes has an article titled "J&J's dirtly little secret" about the toxicity of acetaminophen ( Tylenol ). People die from Tylenol. One statement that was very troublesome "No other over-the-counter drug has a narrower range between therapy and toxicity than acetaminophen". There was one chart that if I read it correctly indicates that acetaminophen leads even cocaine in drug fatalities as reported to poison control centers. I am long J&J. Should I worry?
My sincere wish is that you never have to find out why it wouldn't work for lung cancer. I can't explain it in a few sentences, but believe me, it would not work. I can see it being useful for other types of cancer, but not lung. Drop the speculation, it is painful for those of us who have to deal with the real thing.
Actually, it would allow the operator, either chest surgeon or pulmonologist to cut in separate areas. This is because you can mark with CARTO (Biosense) where you have been. An advantage would be that after visualize the mass, you can make sure that you are removing tissue from different parts of it.
EliasFardo, with the risk of boring others who read this thread, I agree with you. People should be careful. I guess my beef
is that this is a problem that applies to all over the counter drugs. I would have liked to known the toxicity level for
aspirin, ibuprofin, anti-histimines etc. I like Forbes too and agree that they have a good history of turning over the rocks to find
all the bugs. One thing I am excited about is J&J's Cox II drugs, these promise to take a large hunk of the anti-inflammatory
market which is about $5 billion a year. Their web site is very good about keeping people informed. Drug pipeline is one of the
I do think that Forbes had an important point regarding tylenol. The point being that this drug which is advertised as being very safe, can become toxic in rather small dosages. This got poo poo'ed on this board which leads me to believe that some people missed two points completely. (1) Be careful of all drugs, especially with children. (2) Tylenol is advertised by J&J as being especially safe. Any threat to that perception by the public can have financial consequences.
I have been a long time reader of Forbes. 20+ years. I generally have a high opinion of its content. However, I do think it has lost something since the old man died.
In October the ACCP (Chest Physicians) meeting had a report from Johns Hopkins about using Biosense technology in
conjunction with a bronchoscope from a company called Vision Sciences. According to the report, uncertainty about "where to stick the
needle" has kept a minimally invasive procedure called TBNA from being more widely used for lung cancer diagnosis. The conclusion
was that the approach was feasible, and clinical trials are planned. So JNJ is apparently not relying solely on cardiac
applications for the Biosense technology.
Here's a free one. JNJ bought Biosense, a company based out of Haifa, Israel which has a 3-D spatialization system called
CARTO which also uses a Silicon Graphics work station. JNJ apparently paid 400 million. Developed initially for the
electrophysiology field, works great making beautiful pictures. Unfortunately a product looking for an application. Suspect that they bought
it to be used with transmyocardial revascularization via a catheter. Unfortunately another application which may soon go by the
wayside if gene therapy works as anticipated (Phase I trials currently underway at Cornell?).
As a frequent viewer of this board I would appreciate less back and forth on pharmakinetics and toxicity opinions and more on relevant issues that impact this company. While the tylenol franchise is significant, this is a multi-faceted global organization with alot of cutting-edge technology. Let's hear about some more about some of these new developments.