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Prana Biotechnology Limited Message Board

  • pivalde pivalde Mar 28, 2012 12:13 PM Flag

    sAPPalfa in brain injury by Masters

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    • This is not an AD study, however sAPPalfa is very important also preventing AD because when the metabolism of APP is not disturbed it is the stimulator of renewing neural tissue and reparing it as happens in this study. If the metabolism of APP is disturbed because of metal imbalance inside and outside the neuron, the synthesis of aAPPalfa is disturbed and the repare mechanism does not work.

      • 2 Replies to pivalde
      • Thanks Pivalde,

        Here's something else on that subject.


        Red Mold Rice Promotes Neuroprotective sAPPalpha Secretion Instead of Alzheimer’s Risk Factors and Amyloid Beta Expression in Hyperlipidemic Aβ40-Infused Rats

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        Chun-Lin Lee†, Tzong-Fu Kuo‡, Cheng-Lun Wu§, Jyh-Jye Wang and Tzu-Ming Pan*


        † Department of Life Science, National Taitung University, Taitung, Taiwan, Republic of China

        ‡ Graduate Institute of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

        § R&D Division, Sunway Biotechnology Company Limited, Taipei, Taiwan, Republic of China

        Department of Nutrition and Health Science, Fooyin University, Kaohsiung, Taiwan, Republic of China

        Institute of Microbiology and Biochemistry, National Taiwan University, 1, Sec. 4, Roosevelt Road, Taipei, Taiwan 106, Republic of China

        J. Agric. Food Chem., 2010, 58 (4), pp 2230–2238

        DOI: 10.1021/jf904027y

        Publication Date (Web): January 20, 2010

        Copyright © 2010 American Chemical Society

        *To whom correspondence should be addressed. Tel: +886-2-33664519. Fax: +886-2-3366-3838. E-mail: tmpan@ntu.edu.tw.



        Section:

        Food and Feed Chemistry


        Abstract


        Amyloid beta (Aβ) peptide is closely related to the onset of Alzheimer’s disease (AD). A high-cholesterol or high-energy diet was demonstrated to stimulate Aβ formation and deposition in the amyloid precursor protein (APP) pathway and, oppositely, downregulate the secretion of the neuroprotective soluble APP α-fragment (sAPPα). Monascus-fermented red mold rice (RMR) including multiple cholesterol-lowering agents, antioxidants, and anti-inflammatory agents has been proven to ameliorate Aβ40 infusion-induced memory deficit in our previous study. In this study, the ethanol extract of RMR (RE) and natural RMR were respectively tested for their effect on the mediation of the proteolytic process of APP in cholesterol-treated human neuroblastoma IMR32 cell, as well as their effect on memory and learning ability and the expression of AD risk factors in intracerebroventricular Aβ40-infused hyperlipidemic rats. In the results, RE suppressed cholesterol-raised β-secretase activity and further resulted in the increase of sAPPα secretion in the IMR32 cell. In the animal test, RMR potently reversed the memory deficit in the water maze and passive avoidance tasks. RMR administration could prevent against Aβ40 infusion plus the great damage caused by a high energy diet in hippocampus and cortex involved in the raise of thiobarbituric acid reactive substances and reactive oxygen species. The neuroprotection provided by RMR downregulates Aβ40 formation and deposition by suppressing the cholesterol-raised β-secretase activity and apolipoprotein E expression, as well as mediates the proteolytic process of APP toward neuroprotective sAPPα secretion in hippocampus.


        Red mold rice hmmm, gotta check that out.

 
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