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Prana Biotechnology Limited Message Board

  • onlineio onlineio Jan 29, 2013 2:17 PM Flag

    University of New Orleans has NOT discovered a cure for Huntington's disease

    A recent press release from the University of New Orleans (UNO) claims its researchers has discovered a “way to delay symptoms of deadly Huntington's disease”. Music to the ears of HD family members everywhere. But does the science live up to the hype? The short answer, sadly, is no.

    try this

    en dot hdbuzz dot net slash 114

    I don't know much about science but may be someone can provide us better insight that what this mean to Prana.

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    • If you go to the web page onlineio told you will see what Dr. Carroll tells about the value of this paper. But it is also clear if you read the abstract below:
      "Huntington's disease (HD) is a neuropsychiatric disorder characterized by choreiform movement of the limbs, cognitive disability, psychosis and dementia. It is invariably associated with an abnormally long CAG expansion within the IT15 gene on human chromosome 4. Although the mutant huntingtin protein is ubiquitously expressed in HD patients, cellular degeneration occurs predominantly in neurons within the corpus striatum and cerebral cortex. The Ras homolog Rhes is expressed very selectively in the precise brain areas affected by HD. Recent in vitro work suggests that Rhes may be a co-factor with mutant huntingtin in cell death. The objective of the present study was to examine whether the inhibition of Rhes would attenuate or delay the symptoms of HD in vivo. We used a transgenic mouse model of HD crossed with Rhes knockout mice to show that the behavioral symptoms of HD are regulated by Rhes. HD(+)/Rhes(-/-) mice showed significantly delayed expression of HD-like symptoms in this in vivo model. Drugs that block or inhibit the actions of Rhes may be useful as the first treatments for HD".
      It is sad that we have this kind of press releases to claim cure.

      Sentiment: Strong Buy

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