That is the splitting of a protein clogging the heart. Can only be repaired with a transplant. That would be nice if MPACs would work there. Can also be tied to diabetes. That would be fantastic if they could move against that.
The PPS if they prove to be effective against neurodegenerative diseases and then cardiomyopathy. Probably similar to PFEs, but it is a bit soon to be commenting on that.
If you are talking about the current price, it is on Yahoo finance and you can read it there. Hope that helps.