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Prana Biotechnology Limited Message Board

  • pivalde pivalde Apr 25, 2013 2:10 AM Flag

    AD neuronal death in real time by Xie et al, Apr 22, 2013

    Neuronal loss is the ultimate outcome in a variety of neurodegenerative diseases and central nerve system disorders. Understanding the sequelae of events that leads to cell death would provide insight into neuroprotective approaches. We imaged neurons in the living brain of a mouse model of Alzheimer's disease that overexpresses mutant human amyloid precursor protein and presenilin 1 and followed the death of individual neurons in real time. This mouse model exhibited limited neurodegeneration and atrophy, but we were able to identify a small fraction of vulnerable cells that would not have been detectable by using standard approaches. By exploiting a genetically encoded reporter of oxidative stress, we identified susceptible neurons by their increased redox potential. The oxidative stress was most dramatic in neurites near plaques, propagated to cell bodies, and preceded activation of caspases that led to cell death within 24 h. Thus, local oxidative stress surrounding plaques contributes to long-range toxicity and selective neuronal death in Alzheimer's disease.

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    • "By exploiting a genetically encoded reporter of oxidative stress, we identified susceptible neurons by their increased redox potential. The oxidative stress was most dramatic in neurites near plaques"

      I guess that brings plaques back into the picture, right at a time Prana has plaque reduction as a primary end point in a PBT2 trial completing this year.

      Masters noted that 18 months was not long enough for LLYs Sola trial. I recall he sounded very confident when he announced the start of the 12 month IMAGINE trial. It is obvious which he considers the better drug.

      Sentiment: Strong Buy

 
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