This almost makes me ill. By any easily-stated standard the study was ethical and improved the health of patricipants. But it was a search for an identifiable genetic defect in order to recommend that women have surgery, and by no means minor surgery. I consider the near-disappearance of tonsillectomy important medical progress. An increase in precautionary salpingo-oophorectomies strikes me as a disaster in and of itself.
We may live at a moment when this is the best that scientific medicine can offer, but I seriously want to make that moment pass.
We don't need a war on cancer; we need a massive deepening of our understanding of cell biology. We can see the defective genes exactly, here. There ought to be a better way to mitigate the consequences than cutting away the tissues where they act. Soon.