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Insmed Incorporated Message Board

  • rehdvm2004 rehdvm2004 Dec 31, 2012 3:16 PM Flag

    FaceTheFacts INSM Longs - Incidence of CF versus Bronchiectasis

    wwwDOTfreemdDOTcom/bronchiectasis/incidenceDOThtm places the incidence of bronchiectasis at 1 per 100,000 in the US. 300,000,000/100,000 = 3,000 by the calculator on this computer. By comparison, there is an incidence of:

    "According to data collected by the Cystic Fibrosis Foundation, about 30,000 Americans, 3000 Canadians, and 20,000 Europeans have CF."

    This quote comes from a genetic disease website: wwwDOTornlDOTgov/sci/techresources/Human_Genome/posters/chromosome/cfDOTshtml

    So were does speculation leave off and plain BS begin?!?

    Also bronchiectasis is a dilation and scarring of the airways caused by infections, many of which are neonatal diseases. The mucous pools and becomes infected in these enlarged scarred areas of the lungs.

    Sentiment: Buy

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    • CF. The other is Whooping Cough, which is rare but persistant according to CDC. So a CF patient (pre-adolescent) gets their first respiratory infection, the treatment is marginally effective, they cough like crazy which places unnatural pressure and biophysics stress on the airways, the airways dilate and then scar to permanently become predisposed to poor air exchange and pooling of mucous. These dilated airways never heal and result in the lifelong condition called bronchiectasis. Like the reference above indicates, it has an incidence about 1/10 that of CF.

      Either way, both CF and bronchiectasis patients from all causes are subject to respiratory infections their entire lives. Which brings the entire equation back to what bacteria is causing the infection in the firstplace.

      Sentiment: Buy

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