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Insmed Incorporated Message Board

  • insm_truth_teller insm_truth_teller May 19, 2013 8:23 AM Flag

    Inhaled amikacin

    rehdvm2004 • May 9, 2013 10:08 AM
    Pneumonia is different from lung infection. Pneumonia has exudate and "junk" in the alveoli and airways. The antibiotic has to penetrate into mass and the exudate and "junk" has to be cleared from the lungs. Infection (like what Arikace is used to treat) is just bacterial living in the biofilm and macrophages. There is no significant amount of debris to be cleared. Have you ever seen a pneumonia patient being treated? The put this thing around the patient's chest that literally pounds the chest wall to cause vibrationa and loosen the debris in the lungs. They also routinely nembulize at the same time they administer oxygen because the junk makes a barrier to oxygen reaching the bloodstream. Totally different than a person using an inhaler to treat once, twice or three times per day while they are walking around. Pneumonia patients are treated in the hospital BTW while CF and NTM patients are at home with Arikace. So the point is that Arikace treats infections, not pneumonia. But it will still lead to a breakthrough treatment for CF/Pa and NTM infections

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