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Insmed Incorporated Message Board

  • checksurshorts checksurshorts May 31, 2013 2:34 PM Flag

    Interesting Post From NTM Forum

    Found this four-month-old post on NTM News forum:

    "I like to forward an email or contact Insmed, the drug company that has developed the drug Arikace. Do you guys know about the Arikace trial? So far I have heard from two patients who claim that they are doing better and are not experiencing any toxicity. However these pple are also taking the big 3 as well - to which they had not responded in the past 2-3 years. In order to be eligible for the Arikace trial, you should continue taking the big 3 even though you have not responded to them which I think does not make sense! And a few days ago I spoke with one of the participating hospitals that is running the Arikace trial and told her about all those pple who cannot take the big 3 or have become immune to them. She told me that they have also been asking Insmed if they could try to test the Arikace alone for those pple who are not on the drug. So they are aware of it. I would like to urge and beg all those people who are not taking the big 3 to contact Insmed and pressure them to open up another trial just to test the drug on them alone without the other antibiotics. I want to have as many pple as possible to contact that company or write letters to them to make the request. I think if lots of us make that request, then they might accept to test the Arikace alone. I think it's worth a try

    Can we all please take action and not just stay impassive and wait for the drug companies to take years and years to finally develop something for us? We don't have much time."

    Sentiment: Strong Buy

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    • From Rehdvm2004's post below criticizing the claim that NTM trial participants had to be on "the big three." Interesting because patients were required to be on "the big three." ---

      "The concept of using "the big three" concurrently would totally confuse what antibiotic effect was attained with Arikace. This is a Strong Buy now on its objective merits. But the BS manipulations by stock traders go on to get these "untruthful" peaks and dips in the SP. Total manipulations. That is why stockbrokers, bankers and politicians were at the bottom of the "trust list" for professions on the most recent Yahoo poll. Doctors and scientists were near the top, BTW.

      Anyway, lots of red thumbs down are going to appear, but if you are interested in the truth, look at the NIH site which is under Dr. Kenneth N Olivier's oversight.

      WL will quote Dr. Olivier, not the garbage cited above. The only adjuncts that can still be used are 3% saline, Pulmozyme to digest white blood cell "glup", bronchiole dilators and non-antibiotic adjuncts.

      Besides the patient may have gotten placebo in which case the mucous is just thinner."

      Sentiment: Strong Buy

    • michael_coen@ymail.com michael_coen Jun 3, 2013 7:05 AM Flag

      you might want to listen again to the May 7th quarterly conf call, secifically to the Q&A session at the 27 minute marker.

      WL mentioned that Insmed will launch a second open label extension trial for patients with NTM who "do (did) not qualify for the phase 2 trial". Why? because these patients were unable to tolerate the usual regiment of drugs which is (was) a requirement for qualification/entry into the phase 2 trial.
      this "extension trial" is deliberately to allow such NTM patients to access and trial Arikace (exactly as posted on this formum - qudos for finding that! It is NOT a requirement for FDA approval but it is clear from WL comments that it may help label expansion... ;-)

    • I have found the NTMNews site, and and used their internal search engine for terms used in your quote such as "Insmed" and "Arikace", but got no results. I inquired with the info contact, and await their response.
      Then I did an Advanced Google Search at the NTMNews's domain, and found 4 "hits" for "Arikace".
      The post quoted by checksurshorts is at the root of the NTMNews site plus /index.php/forum/welcome-mat/17-arikace-trial . There is no corroboration from the author of the website on the info in this post, nor any further clarification of the details by the poster of this quote, who goes by "apegahi1". Interestingly, this thread at NTMNews, is the "most popular" with a total of 11 posts representing the conversation between the originator of the thread and the website moderator (see /index.php/forum/statistics ).

      Searching the web for the thread originator's moniker "apegahi1" finds posts at maclungdiseaseDOTorg, but those pages are deleted. Info on NTMNews suggests that maclungdisease has deleted posts which question the efficacy of traditional pharmaceutical treatments. It seems that "apegahi1" is someone who has actually been caring for a relative with NTM who is not participating in the Insmed trial, but is desperately searching for an actual cure.

    • This is why posts like this are manipulations:

      NIH Clinical Trials site listing the study 12-I-0133.

      Exclusion criteria:

      "16. Use of inhaled antibiotics, systemic aminoglycosides (e.g., tobramycin, amikacin, gentamicin or streptomycin) from the screening visit through Study Day 1 (including at least 28 days prior to Study Day 1). "

      The concept of using "the big three" concurrently would totally confuse what antibiotic effect was attained with Arikace. This is a Strong Buy now on its objective merits. But the BS manipulations by stock traders go on to get these "untruthful" peaks and dips in the SP. Total manipulations. That is why stockbrokers, bankers and politicians were at the bottom of the "trust list" for professions on the most recent Yahoo poll. Doctors and scientists were near the top, BTW.

      Anyway, lots of red thumbs down are going to appear, but if you are interested in the truth, look at the NIH site which is under Dr. Kenneth N Olivier's oversight.

      WL will quote Dr. Olivier, not the garbage cited above. The only adjuncts that can still be used are 3% saline, Pulmozyme to digest white blood cell "glup", bronchiole dilators and non-antibiotic adjuncts.

      Besides the patient may have gotten placebo in which case the mucous is just thinner.

      Sentiment: Strong Buy

      • 2 Replies to rehdvm2004
      • "This is why posts like this are manipulations:"
        Who are these "manipulators"? ......do you honestly think this board and trading have any linkage whatsoever?
        Rest assured, the "short are getting crushed (THEY were the movers to 13.40) are silly.Good Luck

      • I will try again.

        Not manipulating. Just like to post info related to my investment I think may be relevant and use OPT to help sort it out.

        You posted:

        16. Use of inhaled antibiotics, systemic aminoglycosides (e.g., tobramycin, amikacin, gentamicin or streptomycin) from the screening visit through Study Day 1 (including at least 28 days prior to Study Day 1).

        So "the big three" is inhaled?

        If not then what is this from exclusions:

        17. Any change in chronic NTM multi-drug regimen within 28 days prior to Study Day 1.

        And this from inclusions:

        5. Receiving ATS/IDSA guidelines-based treatment regimen defined as: adherent to a multi-drug regimen for at least 6 months prior to screening with persistently positive mycobacterial cultures.

        I don't know. I could look it up but I do enjoy using OPT.

    • Gotta Link? Some context and info on followup, etc. would be useful.

 
INSM
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