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Insmed Incorporated Message Board

  • sigma_capitals sigma_capitals Aug 2, 2013 11:02 PM Flag

    PLEX News: Researchers Identify Novel Therapy to Treat Muscular Dystrophy

    An article very similar to this was was published in June by "Science Daily". This one was just published by "Human Molecular Genetics" and featured on Google finance about Insmed. Yahoo won't let me post a link. Go to Google to find article. Very promising.

    August 2, 2013 - "Researchers at Boston University College of Health & Rehabilitation Sciences: Sargent College have identified a combinatorial therapeutic approach that has proven effective in treating muscular dystrophy in a mouse model. The findings, published in Human Molecular Genetics, represent a paradigm shift for the treatment of muscular dystrophy as well as a host of other disabling and devastating muscle diseases..."

    ..."The research team studied the outcome of combining the following single mode treatments: increasing regeneration, by overexpressing muscle specific insulin like growth factor-1, IGF-1 and preventing cell death, by inhibiting the expression of Bax, a pro-apoptotic protein. In addition, to test the translational potential of this combination therapy, the researchers systemically treated Bax deficient dystrophic mice with recombinant human IGF-1 (IPLEX TM, manufactured by Insmed Inc)."

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