PLEX News: Researchers Identify Novel Therapy to Treat Muscular Dystrophy
An article very similar to this was was published in June by "Science Daily". This one was just published by "Human Molecular Genetics" and featured on Google finance about Insmed. Yahoo won't let me post a link. Go to Google to find article. Very promising.
August 2, 2013 - "Researchers at Boston University College of Health & Rehabilitation Sciences: Sargent College have identified a combinatorial therapeutic approach that has proven effective in treating muscular dystrophy in a mouse model. The findings, published in Human Molecular Genetics, represent a paradigm shift for the treatment of muscular dystrophy as well as a host of other disabling and devastating muscle diseases..."
..."The research team studied the outcome of combining the following single mode treatments: increasing regeneration, by overexpressing muscle specific insulin like growth factor-1, IGF-1 and preventing cell death, by inhibiting the expression of Bax, a pro-apoptotic protein. In addition, to test the translational potential of this combination therapy, the researchers systemically treated Bax deficient dystrophic mice with recombinant human IGF-1 (IPLEX TM, manufactured by Insmed Inc)."
Researchers at Boston University, supported in part by MDA, say their experimental two-pronged strategy for merosin-deficient congenital muscular dystrophy (MDC1A) was highly successful in a mouse model of this disease and should be further investigated as a potential treatment approach for patients.
Now, MDA research grantee Mahasweta Girgenrath and colleagues have shown that simultaneously counteracting cell death and providing a growth-promoting protein improved muscle health and function in mice with an MDC1A-like disorder.
2. An older publication -
Muscle-specific expression of insulin-like growth factor 1 improves outcome in Lama2Dy-w mice, a model for congenital muscular dystrophy type 1A
Tanya Girgenrath and
Received December 14, 2010.
3. A study in Finland published in 2012 -
Native and Complexed IGF-1: Biodistribution and Pharmacokinetics in Infantile Neuronal Ceroid Lipofuscinosis
Any guesses as to where they got the Complexed IGF-1?
You'll probably find there's a lot of it out there - and it's been out there for a long time.