what ever happened with this?
Researchers Identify Novel Therapy to Treat Muscular Dystrophy
"Very few studies have utilized the power of combinatorial therapy in the context of muscular dystrophy." said Professor Girgenrath, the study's corresponding author. "While most MD treatments are single-target therapies, we're delving into combinations of different therapies to target multiple pathways."
The research team studied the outcome of combining the following single mode treatments: increasing regeneration, by overexpressing muscle specific insulin like growth factor-1, IGF-1 and preventing cell death, by inhibiting the expression of Bax, a pro-apoptotic protein. In addition, to test the translational potential of this combination therapy, the researchers systemically treated Bax deficient dystrophic mice with recombinant human IGF-1 (IPLEX TM, manufactured by Insmed Inc).
On another note, the trial, "Insulin-Like Growth Factor I (IGF-I) in the Prevention of Complications of Preterm Birth" is ongoing, but not recruiting participants. In June of this year, it was estimated that the study completion date and final data collection date for primary outcome measure would occur in December 2013. So it should not be long before the focus is once again on IGF1/BP3 and with it, news on plans for renewed manufacturing.
with a list like this I don't see why they roche would not be making a deal with insm for iplex - and add Muscular Dystrophy to the list
Aetna considers mecasermin (Increlex) and mecasermin rinfabate (Iplex)* experimental and investigational for the following indications (not an all inclusive list):
Prevention of hearing loss
Prevention of retinopathy of prematurity
Treatment of AIDS muscle wasting
Treatment of amyotrophic lateral sclerosis
Treatment of Alzheimer's disease
Treatment of anorexia nervosa
Treatment of burns
Treatment of chronic liver disease
Treatment of Crohn's disease
Treatment of cystic fibrosis
Treatment of extreme insulin resistance
Treatment of HIV-associated adipose redistribution syndrome (HARS)
Treatment of ischemic heart disease
Treatment of myotonic muscular dystrophy
Treatment of osteoporosis
Treatment of partial GH resistance
Treatment of spinal cord injury
Treatment of X-linked severe combined immunodeficiency
Treatment of Werner syndrome