Guess what ole' Merck and Insmed have been working on...
Here's a clue:
In this study, we found that treatment with HDAC inhibitors reinstated antitumor effects of IGFBP-3 by downregulating PKC-mediated degradation of IGFBP-3 and thus restoring the effects of IGFBP-3 on Akt activation and apoptosis. These results implicate PKC activation, presumably through myriad pathways, in the mechanisms of intrinsic resistance to IGFBP-3. Our findings suggest combined treatment approaches with IGFBP-3 and HDAC inhibitors as effective therapeutic strategies for patients with NSCLC and HNSCC possessing high PKC activity.
We thank Merck and Co. Inc. and Insmed Pharmaceuticals for providing SAHA and recombinant IGFBP-3 protein, respectively.
Heh, heh, heh... This study was published Nov. 15, 2013 and is super-hard to access by word searches. Go figure! Thanks to underdogs for sending me the link.
Sentiment: Strong Buy
When reading the acknowledgements I learned that Merck and Insmed independently supplied different product to this research team. It might be a stretch to suggest that Merck and Insmed have been working together.
Meanwhile, this certainly confirms that igfbp3 is not dead, and that Insmed's pipeline is deceptively robust.
Int J Cancer. Author manuscript; available in PMC 2013 November 15.
Published in final edited form as:
Int J Cancer. 2012 November 15; 131(10): 2253–2263.
Published online 2012 March 28. doi: 10.1002/ijc.27509
Just to be clear, this paper is not new. It is almost 2 years old. Also, there is some confusion about the biosimilars facility in Boulder...Merck folded the bioventures unit into research labs. From what I recall, bioventures folded in 2010 when Kamarck left, but this does not mean Merck is out of biosimilars.
LOL.....thanks for that, pianoman. I just made a notation of igfbp3 in a response to rbalboa today.
Here is what I did if anyone wants to access this information. Copy the paragraph that starts with "In this study" and ends with "PKC activity". Then paste that into google and you will find a link there. WOW!!!