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  • blank2thisone blank2thisone Apr 8, 2014 5:52 AM Flag

    !! Ouch New Study - NTM Mortality = FDA will urge, will declare Arikayce Breakthrough !!

    The NTM prevalence was 1.8 per 100,000 in the US during 1980s. [20] Winthrop et al. reported its prevalence was 8.6 per 100,000 in Oregon, USA in the 2005–2006, with an age-adjusted prevalence of 20.4 per 100,000 in those over 50 years old. In that cohort, the median age was 66 years and 59% were women. [5] A recent nationwide study in the US by Adjemian et al. showed the prevalence of NTM disease was increasing across all regions in the elderly. [21] Between 1997 and 2007, the annual prevalence increased from 20 to 47 cases/100,000 persons, or 8.2% per year among patients whom covered by Federal Health Insurance Program (Medicare beneficiaries). The period prevalence for this time was 112 cases/100,000 persons and was twice as much in Asians/Pacific Islanders as whites (228 vs. 116 cases/100,000 persons).

    Our study also demonstrates the increase in numbers of NTM-related mortality from 1999 to 2010. We also show a striking association between NTM death and age, consistent with the analogous association between NTM prevalence and age. Given the increasing median age in North America, the prevalence and mortality of the mycobacterial disease will most probably increase. [22] In fact, the current increase in NTM disease in North America and the world could be explained, in part, by aging populations. [23].

    Our study also points out the strong correlations between NTM-related mortality with many other medical conditions. The correlation with smoking, hematologic malignancy and HIV is stronger than with tuberculosis. As these chronic conditions increase, the risk of death from nontuberculous mycobacterial infection increases. It is important to note that many of the associated conditions involve mucus pooling in the airways or decrease clearance. The overwhelming percentage of disease being confined to the lung also favors an airway defense mechanism defect as a cause of NTM-disease.

    Source: Pubmed Nontuberculous mycobacterial disease mortality

    Sentiment: Strong Buy

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