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Insmed Incorporated Message Board

  • biowatchdog biowatchdog Jul 25, 2014 3:35 PM Flag


    Does anyone know what would happen if Gallium were added in the LAI formulation?

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    • This Gallium (LOL)?
      Although gallium has no known role in biology, it mimics iron(III), the gallium ion localizes to and interacts with many processes in the body in which iron(III) is manipulated. As these processes include inflammation, which is a marker for many disease states, several gallium salts are used, or are in development, as both pharmaceuticals and radiopharmaceuticals in medicine. When gallium ions are mistakenly taken up by bacteria such as Pseudomonas, the bacteria's ability to respire is interfered with and the bacteria die. The mechanism behind this is that iron is redox active, which allows for the transfer of electrons during respiration, but gallium is redox inactive. Gallium maltolate has high bioavailability and the gallium is antiproliferative to pathologically proliferating cells, particularly cancer cells and some bacteria, due primarily to its ability to mimic ferric iron (Fe3+).

      Gallium nitrate (brand name Ganite) has been used as an intravenous pharmaceutical to treat hypercalcemia associated with tumor metastasis to bones. Gallium is thought to interfere with osteoclast function. It may be effective when other treatments for maligancy-associated hypercalcemia are not. Gallium maltolate, an orally absorbable form of gallium(III) ion, is in clinical and preclinical trials as a potential treatment for a number of types of cancer, infectious disease, and inflammatory disease.

      Sentiment: Buy

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