I followed the Baker Bros and loaded up in the mid 20's. However, there have been several ups and downs since I bought. The downdrafts have been severe enough to make me kick myself for not harvesting some gains by taking something off the table. I'm a strong believer that the prostate test will be a game changer. The Cleveland clinic testing and support bodes well. However, the value will have to be confirmed in several peer reviewed medical journals before there will be really widespread acceptance. Till then I think the sales ramp will be steady in the low double digit range. Eventually insurers will become big backers since the test will save millions of unnecessary procedures. This and geographic expansion will fuel many years of growth I might want to consider a pair trade where I might eventually short the makers/operators of proton treatment for prostate cancer. Competition can always change the landscape but for now GHDX looks to be well situated. I've decided to maintain a strong core holding and write covered calls on about 25% of my holdings when the share price reaches lofty periods.