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Venaxis, Inc. Message Board

  • mcj96 mcj96 Apr 28, 2010 11:26 AM Flag

    Needle in arm(Appy's test) or urinate in a cup

    LRG test kit. Which would you prefer ?

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    • quote:
      Blood Test. Urine test you speak of does not have a better detection rate. And, this urine test you speak of is not even in Phase I of testing. Meaning, it won't be ready to be filed for FDA for another 5 years.


      Also that urine test marker LRG does not even have an ELIZA test - so will need formulation of an ELIZA test that works reliably. And then the cassette form if possible, before it can compete with APPYScore ELIZA test and upcoming cassette (15 minute) version.

      Also the results of the LRG are very close to the APPY marker (S100-A8):

      http://www.genomeweb.com/proteomics/protein-biomarker-may-lead-urine-based-test-childhood-appendicitis?page=show
      Protein Biomarker May Lead to Urine-based Test for Childhood Appendicitis
      June 25, 2009
      By Tony Fong

      ...
      Another of the candidate biomarkers identified by the researchers, S100-A8, is currently being investigated by AspenBio Pharma as a blood-based appendicitis biomarker.



      http://www.ncbi.nlm.nih.gov/pubmed/19556024
      Ann Emerg Med. 2010 Jan;55(1):62-70.e4. Epub 2009 Jun 25.
      Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry.
      ...
      RESULTS: Test performance of 57 identified candidate markers was studied in 67 patients, with median age of 11 years, 37% of whom had appendicitis. Several exhibited favorable diagnostic performance, including calgranulin A (S100-A8), alpha-1-acid glycoprotein 1 (orosomucoid), and leucine-rich alpha-2-glycoprotein (LRG), with the receiver operating characteristic area under the curve and values of 0.84 (95% confidence interval [CI] 0.72 to 0.95), 0.84 (95% CI 0.72 to 0.95), and 0.97 (95% CI 0.93 to 1.0), respectively.

    • Blood Test. Urine test you speak of does not have a better detection rate. And, this urine test you speak of is not even in Phase I of testing. Meaning, it won't be ready to be filed for FDA for another 5 years.

      So um, yeah, APPY in every way.

 
APPY
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