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Venaxis, Inc. Message Board

  • deathground1 deathground1 May 8, 2010 5:41 PM Flag

    98 NPV? You eat fish 'n' paint chips for dinner?

    Ha ha ha ha ha ha! 98 NPV? Ridiculous. It don't work like that bagies. This stock is worth maybe $2 with their animal products. Hilarious hearing monkeys on this board talking about appyscore having a 98 npv. Dilusional fcking gambling junkies. Best of luck bagies. I've bought my puts and will be shorting this joke when it foolishly moves up to the 3.90's again.

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    • First of all I usually will not respond to idiots like you. But for the rest of the board there are many approved test with less than 95% NPVs.

      Take a look at Troponin I, cardiac enzyme which is approved by the FDA for heart attacks. It has a Sensitivity of 90.7% and NPV 84.1%

      Keller, Till, et al., Sensitive Troponin I Assay in Early Diagnosis of Acute Myocardial Infarction. NEJM. Volume 361:868-877.


      Background Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial infarction.

      Methods In a multicenter study, we determined levels of troponin I as assessed by a sensitive assay, troponin T, and traditional myocardial necrosis markers in 1818 consecutive patients with suspected acute myocardial infarction, on admission and 3 hours and 6 hours after admission.

      Results For samples obtained on admission, the diagnostic accuracy was highest with the sensitive troponin I assay (area under the receiver-operating-characteristic curve [AUC], 0.96), as compared with the troponin T assay (AUC, 0.85) and traditional myocardial necrosis markers. With the use of the sensitive troponin I assay (cutoff value, 0.04 ng per milliliter) on admission, the clinical sensitivity was 90.7%, and the specificity was 90.2%. The diagnostic accuracy was virtually identical in baseline and serial samples, regardless of the time of chest-pain onset. In patients presenting within 3 hours after chest-pain onset, a single sensitive troponin I assay had a negative predictive value of 84.1% and a positive predictive value of 86.7%; these findings predicted a 30% rise in the troponin I level within 6 hours. A troponin I level of more than 0.04 ng per milliliter was independently associated with an increased risk of an adverse outcome at 30 days (hazard ratio, 1.96; 95% confidence interval, 1.27 to 3.05; P=0.003).

      Conclusions The use of a sensitive assay for troponin I improves early diagnosis of acute myocardial infarction and risk stratification, regardless of the time of chest-pain onset.

      I would say anything at or north of 90% on the NPV and sensitivity side would be excellent.

      • 1 Reply to joe11mdsuny
      • Good post.

        And Dr. Robert Caspari who took Troponin-T test (for diagnosis of myocardial infarction) through FDA approval was hired by Faulkner in the new management following the 600 patient trial "failure".

        Also the difference is that with appendicitis you can observe patient over time with APPYScore also (something which may or may not be possible with a heart attack victim) - which greatly expands the potential use of APPYScore.

    • Adam F. Said it first. Read his article. "with the loosened sensativity and white blood cell test, NPV should be 98%". I thought it was a good read and definately bullish on APPY...although Adam does state to "be careful".

      I'd be happy with anything north of 95%. Hopefully company achieves 98%. We'd all be rich.

      One thing to look for. A sharp rise in SP to $5 or more, could be a pump to exit prior to bad results. IMO. I would recommend taking most off the table if you don't want to lose your shorts....if the SP heads that high.

      Have fun.

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