Adipose Stromal Vascular Fraction Cells getting a lot of attention lately
Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential
Angiogenesis, 05/03/2013 Clinical Article
Lin RZ et al. – Blood–derived endothelial colony–forming cells (ECFCs) have robust vasculogenic potential that can be exploited to bioengineer long–lasting human vascular networks in vivo. However, circulating ECFCs are exceedingly rare in adult peripheral blood. Because the mechanism by which ECFCs are mobilized into circulation is currently unknown, the reliability of peripheral blood as a clinical source of ECFCs remains a concern. Considering the unreliability and low rate of occurrence of ECFCs in adult blood and that biopsies of WAT can be obtained with minimal intervention in an ambulatory setting,the results indicate WAT as a more practical alternative to obtain large amounts of readily available autologous ECFCs for future vascular cell therapies.