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Optimer Pharmaceuticals, AŞ Message Board

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  • jiarealty jiarealty Nov 15, 2011 6:14 PM Flag

    My challenge to this message board...

    In fact,most people that have taken amoxicillin for respiratory infection that have experienced a diarrhea has a case of mild c.diff case. C.diff diarrhea is more common than you think. Before you make any assumptions, I am giving you 2 tasks. (1) go to walgreens and ask the pharmacist when was the last time they dispensed fidax (2) go to an hospital and ask a pharmacist if fidax have replaced vancomycin on protocol and if not why... After you have done your due diligence,you will understand why optr is sliding in price. I am long on optr because I do believe fidax is a good drug. In fact when FDA approved (I knew it would) I made a huge profit. But after FDA approval,optr has been sliding in price because wall street expectation of what fidax can do is way over estimated. Fidax plays a very niche role in treating c.diff. Those that are in healthcare knows this. If anyone that is a pharmacist or a physician please post and educate the message board about the role of fidax in real clinical practiice. After you have consulted a pharmacist or a physician, please post with your findings. For now, you are making assumptions based on what you have read and not what is really happening in hospitals. I assure you if fidax was that hot, it does not take any time for physicians to jump on board. I can name numerous fantastic drugs that have taken healthcare by storm that changed the way we practice (zosyn, levaquin,merropenem), I assure you fidax is not one of them. Fidax is a small potato and nowhere close to a billion dollar block buster. After you spoke to a pharmacist or physician,tell me what they said.... You will see the light soon.

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    • ...guess you expect immediate adoption, or no adoption; not me. I understand there is education before acceptance, and the adoption of fidax will be forthcoming, in "large doses" by many, many hospitals and physicians. I have written to Optimer, asking that they consider using physician testimonials to offset ridiculous comments such as the ones you've made on this board. if you are a doc, why have you not yet answered my questions regarding treating your own c-diff patients (especially the elderly) with fidax vs. vanco "slurpie"? and, if you can find anywhere at the FDA that vanco is indicated as a "first-line" treatment for c-diff, I'd appreciate the reference; not saying it doesn't exist, just haven't found it yet. remember, the words "first-line treatment" from the FDA, or other credible source. thanks in advance, but please answer the question re: treatment with vanco when clinical data shows better results in first 12 days of treatment using fidax...thanks again.

      • 1 Reply to loriskhireward
      • Here is what I do....when patient have c.diff I identify the underlying cause. If due to long term oral antibiotic use, I switch to another antibiotic or consider giving IV (bypasses the gut) or even a probiotic (i.e. Florastor: populate your gut with competining bacteria thus halting C.diff growth). In most cases, C.Diff diarrea will stop. If C.Diff is not due to oral antibiotic use, I look at patient history. If this is the first time event than empirically you treat with vancomycin. Most hospital pharmacy make oral vancomycin suspensions from IV vancomycin prepared in the sterile environment of the IV room. Dirt cheap. If the patient had C.diff before I look to see if the C.diff diarrea is due to re-infection or or other causes (such as unsanitary conditions) leading to the event. Again in most cases, using vancomycin and adhering to proper hygiene works very well. Only in a small group of patients would you consider Fidax if all of the above have failed to correct the issue. Prudent use of antibiotics is the best way to combat resistance. Here is what the numbers looks like: 100 (patient with C.Diff)- 80 (patients responding to vancomycin on first treatment)= 20 patients. Out of the 20 patients, that did not respond, 18 patients had a re-infection that why "recurrence" occured. Again, these 18 patients will respond to vancomycin. Therefore, you have 2 patients that may possibly benefit from Fidax. Because the number of patient benefiting from Fidax is so small, and Fidax is the only big gun you can go for if you really need it, Fidax in all the hospitals are reserved as a second line agent. Fidax market is much smaller than you are led to believe. Because you want Fidax to work for the 2 patients that really need it, you do not abuse Fidax causing it to lose its potency with resistance. I hope this makes perfect sense to you. I apologize for getting upset on the board but I was expecting way too much knowledge from people not from the healthcare field. if you doubt my rationale, ask any hospital pharmacist or even check with Walgreens. Fidax is rarely dispensed. OPTR has price has been sliding because after the "wow" factor is gone, reality of how small Fidax market really is sets in...

    • mikeadd Nov 21, 2011 4:12 PM Flag

      I've spoken to numerous healt c