Went to pubmed. Nothing on sepsis and cytosorb filter. This abstract reads like ancient history and all the failed therapies. Sounds like best treatment for sepsis is prayer, as it has been for years. So my issue with this is how CTSO has been approved for 2.5 years, numerous conferences and opportunities to sell the filter and we can't get mentioned in a current assesment of sepsis. What's wrong with this picture. Maybe pings newsletter news will lead to something??
Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets-An Updated View.
Schulte W, Bernhagen J, Bucala R.
Department of Internal Medicine, Yale University School of Medicine, The Anlyan Center, S525, P.O. Box 208031, 300 Cedar Street, New Haven, CT 06520-8031, USA ; Institute of Biochemistry and Molecular Cell Biology, University Hospital of RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
Sepsis and septic shock are among the leading causes of death in intensive care units worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the inflammatory network leading to tissue damage, organ failure, and ultimately, death. Cytokines are important pleiotropic regulators of the immune response, which have a crucial role in the complex pathophysiology underlying sepsis. They have both pro- and anti-inflammatory functions and are capable of coordinating effective defense mechanisms against invading pathogens. On the other hand, cytokines may dysregulate the immune response and promote tissue-damaging inflammation. In this review, we address the current knowledge of the actions of pro- and anti-inflammatory cytokines in sepsis pathophysiology as well as how these cytokines and other important immunomodulating agents may be therapeutically targeted to improve the clinical outcome of sepsis.