Did anyone notice that big old nasty Aniline moiety hanging off solithromycin? anilines are known as liver killers...bromphenac and Tylenol are just couple that pop to mind...However in Tylenol's case anilines are produced when 70% of glutathione is used getting this poison out of your system. anyway, I want to see the liver data on cemp's drug before I pile in. TZD is best drug in this space...hands down.
Now we enter the shakeout and wear down phase of our tsrx journey, don't getting shaken out, this is a 20 dollar stock... no question.
Okay to nix Solithromycin, a hand grenade for one's liver but what's Cemp's other drug Taksta looking like? So far this fusidic acid based drug is only comparable, not better than linezolid in phase 2 results and develops resistance with less optimal initial dosing. So far TZD leads the race in this space.
yes...on the surface of it fusidic acid looks comparable but only in phase 2...Phase 2 studies only use small hand picked populations...when this goes into phase 3 I would not be at all surprised to see it fall short against LZD and far shy of TZD. Besides Fusidic acid has known liver toxicity and apparently you cannot take it with statins because of fatal rhabdomyelysis. TZD is safe all around.
And Resistance is readily acquired when fusidic acid is used alone and commonly develops during the course of treatment. As with most other antibiotics, resistance to fusidic acid arises less frequently when used in combination with other drugs(=more side effects)...Again TZD wins....now that TZD can be combined with Cubicin for MRSA and Bacteremia....please... cempra has no chance of beating Trius.